Annotation Overview for fig|264198.3.peg.5065 in Ralstonia eutropha JMP134:
RND efflux system, inner membrane transporter CmeB

current assignment	RND efflux system, inner membrane transporter CmeB
taxonomy id	264198	contig	264198.3:NC_007336 (634,918bp)264198.3:NC_007337 (87,689bp)264198.3:NC_007347 (3,806,534bp)264198.3:NC_007348 (2,726,153bp)
internal links	genome browser | feature evidence | sequence	ACH Annotation Clearinghouse (ACH) The Annotation Clearinghouse offers a mapping of genes which are identical in sequence except for the start region (due to differences in start calling). [?]	show essentially identical genes
annotation history		run tool	Psi-BlastTMpredTMHMMGram negative PSORTGram negative SignalPGram positive PSORTGram positive SignalPLipoPInterProScanRadarPPSearchGram negative CELLOGram positive CELLOProDomPDB
FigFam	FIG085263
data base cross references (dbxref)	UniProt: Q46TT9_RALEJ NCBI: 72121259 UniProt: Q46TT9 RefSeq: YP_298289.1 NCBI: 73537922 CMR: NTL01REA0626

Annotation History (history of similar genes)

Date	Annotator	Annotation
11/30/2004	RossO	Set FIG function to acridine efflux pump
9/2/2005	annotation_repair	Annotation for existing assignment RND multidrug efflux transporter that did not match latest annotation acridine efflux pump
9/2/2005	annotation_repair	Set FIG function to RND multidrug efflux transporter
7/5/2007	OlgaZ	Set FIG function to Inner membrane efflux transporter of RND family multidrug efflux pump
7/5/2007	OlgaZ	PMID: 16614254
1/14/2009	OlgaZ	Set FIG function to RND efflux system, inner membrane transporter CmeB
1/14/2009	OlgaZ	Role changed from 'Inner membrane efflux transporter of RND family multidrug efflux pump' to 'RND efflux system, inner membrane transporter CmeB'
1/14/2009	OlgaZ	Master function set by OlgaZ at 1231956036 RND efflux system, inner membrane transporter CmeB

We have assigned the function "RND efflux system, inner membrane transporter CmeB" to the encoded protein. The protein occurs in 1 subsystem: "Multidrug Resistance Efflux Pumps". In "Multidrug Resistance Efflux Pumps", it occurs in close proximity on the chromosome with 2 other genes from the same subsystem. The function of genes having the same functional roles have been described in Escherichia coli (7651136) and Campylobacter jejuni (16735430). These are homologous proteins which implement the same function.

The chromosomal region of the focus gene (top) is compared with four similar organisms. The graphic is centered on the focus gene, which is red and numbered 1. Sets of genes with similar sequence are grouped with the same number and color. Genes whose relative position is conserved in at least four other species are functionally coupled and share gray background boxes. The size of the region and the number of genomes may be reset. Click on any arrow in the display to refocus the comparison on that gene. The focus gene always points to the right, even if it is located on the minus strand.